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KMID : 0616120200510010041
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Korean Journal of Pharmacognosy
2020 Volume.51 No. 1 p.41 ~ p.48
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The Effect of Glucopyranosyldiacylglycerol from Padina arborescens on the Prevention of Hair-Loss
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Kang Jung-Il
Kim Jung-Eun
Kim Sang-Chul
Han Sang-Chul
Lee Ji-Hyeok
Lee Jae-Hyun
Noh Eui-Jun
Jeon You-Jin
Yoo Eun-Sook
Kang Hee-Kyoung
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Abstract
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This study was conducted to evaluate the effects of Padina arborescens and 1?O?myristoyl?2?O?oleoyl?3?O?(a?D?glucopyranosyl)?glycerol(MOGG), its active component, on the prevention of hair loss. The P. arborescens extract and MOGG inhibited the activity of 5a-reductase, which converts testosterone to dihydrotestosterone(DHT), a main cause of androgenetic alopecia. When immortalized rat vibrissa dermal papilla cells were treated with MOGG, the proliferation of dermal papilla cells signi?cantly increased. In addition, we found that the P. arborescens extract and MOGG could open the KATP channel, which may contribute to increase hair growth. Furthermore, MOGG promoted PGE2 production in HaCaT cells. The results suggest that MOGG from the P. arborescens extract has the potential to treat alopecia via 5a-reductase inhibition, the proliferation of dermal papilla, the opening of the KATP channel and/or increase of PGE2 production.
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KEYWORD
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Padina arborescens, Glucopyranosyldiacylglycerol, Hair-loss, 5a-Reductase, KATP channel, Dermal papilla cell
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